Degradation of muramyl dipeptide by mammalian serum.
نویسندگان
چکیده
Muramyl dipeptide, N-acetylmuramyl-L-alanine-D-isoglutamine (MDP), is the minimal biologically active subunit of bacterial peptidoglycan and elicits an acute inflammation in vivo. We now report that MDP is degraded by normal rat serum into its constituents, N-acetylmuramic acid and L-alanine-D- isoglutamine. The dipeptide is further degraded into its components L-alanine and D-isoglutamine. These results may help to explain how inflammation elicited by MDP is terminated in vivo.
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عنوان ژورنال:
- Infection and immunity
دوره 50 1 شماره
صفحات -
تاریخ انتشار 1985